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It began with the desire to develop cosmetic products that meet all female skin.Hiroko Science Series

It began with the desire to develop cosmetic products that meet all female skin.

Microscopic view of skin cells growing up healthy.

Beautiful skin to all
Great days enjoying beautiful skin

HiRoko Science, Inc. was founded by Dr. Hiroko Yanaga and her husband Dr. Katsu Yanaga.
HiRoko Science Series Cosmeceuticals are born as the result of more than 25 years of highly advanced skin research conducted by Dr. Hiroko Yanaga.

"Cosmeceuticals" is a term that combines the words cosmetics and pharmaceuticals, products that help not only improve the appearance of the skin from the outside but also contain active ingredients that modify and help improve the appearance of the skin from the inside.

Choosing the most effective active ingredients and their optimum mix is what defines the quality of a cosmeceutical and that is where Dr. Hiroko Yanaga has excelled. Her vast clinical and research experience has allowed her to find a very effective formulation of active ingredients that are the base of the Hiroko Science Series and help her achieve her goal of creating cosmeceuticals that are based on Science, a scientific and not commercial approach to product creation, on Simplicity, a narrow line of products that work effectively with all kinds of skins and on Safety, products that are safe for everyone to use. This is what she calls the 3S (Science, Simplicity and Safety).

Dr. Hiroko Yanaga is a pioneer in regenerative medicine in Japan. She has been doing research and clinical applications using cultured epidermal stem cells (skin) and using cell therapy to treat and repair damaged skin for more than 30 years. Her vast experience led her to identify the ideal mix of active ingredients that would provide aged or damaged skin cells with the necessary nutrients to bring them back to their normal, healthy and beautiful condition.

A women's skin needs special care and it might be affected by different conditions such as problems with the pores, dark spots, acne, wrinkles, stains, uneven color, dullness or dry skin. Dr. Yanaga's goal has always been to help bring back healthy skin to women suffering from any of those conditions. She believes that solving those skin problems will help women enjoy more fulfilling lives.

Rather than just covering skin troubles with plain cosmetics, let's improve the skin from within and regain healthy skin and enjoy life even more.

You will notice an improvement in the quality of your skin from the next day you start using HiRoko Science products. The combined and continued use of our line of products for a year lets you experience even greater results.

Development doctor introduction · BiographyDevelopment doctor introduction · Biography

Hiroko Yanaga

Presentation at Harvard University

At Harvard University

Presenting at Harvard University


矢永博子 写真

Department of plastic surgery · cosmetic surgery · reconstructive surgery · anesthesiology · tissue regeneration laboratory medical institution

  • ◆ Doctor of Medicine
  • ◆ Japan Society of Plastic Surgeons Certified Specialist
  • ◆ Japan Society of Aesthetic Plastic Surgery Certified Specialist
  • ◆ Japan Association of Cosmetic Medicine Certified Doctor
  • ◆ Japan Society for Burn Injuries Specialist
  • ◆ Japan Breast Cancer Society Councilor
  • ◆ Japan Society for Burn Injuries Councilor
  • ◆ The Japanese Society for Regenerative Medicine Councilor
  • ◆ American Society of Plastic Surgeon (ASPS) member
  • ◆ International Society of Aesthetic Plastic Surgery (ISAPS) member
  • ◆ International Cartilage Repair Society (ICRS) member

Graduated from St. Marianna University School of Medicine School of Medicine in 1983. She then obtained an specialization in plastic surgery from St Marianna University in 1985 and she conducted post-doctoral studies at Harvard University (Cellular and Molecular Biology Institute) in 1989. After working as a Plastic Surgeon and a Plastic Surgery instructor at St. Marianna University School of Medicine and Kurume University for more than 10 years she opened Yanaga Clinic in 2001. Concurrently with her practice she is still a St. Marianna University School of Medicine lecturer. She participates actively in professional specialist societies and congresses in Japan and abroad to stay updated on the latest research and optimal available treatments. She is also a popular lecturer and invited guest at universities, seminars and public lectures. Besides being an expert in the treatment of aging of the skin (stains, wrinkles, sagging), acne, the treatment of acne scars and skin care in general she also has vast experience and is well known for her advanced techniques in breast reconstruction surgery, breast augmentation, breast reduction, all breast-nipple-areola surgery, cultured cartilage, cultured epidermal, cultured fibroblasts treatments, rhinoplasty, face lift, fat injection and liposuction, lower eyelid surgery and other various types of plastic and cosmetic surgery. Dr. Hiroko Yanaga is an accomplished scientist and researcher who places great importance in the practical applications of her research.

  • Presentation at Harvard University

  • At Harvard University

  • Presenting at Harvard University

Media informationMedia information

  • ◆Featured article on "Yomiuri Shimbun"newspapper, June 21, 2016 issue
  • ◆Featured article on "Shukan Bunshun" weekly magazine, June 3, 2010 issue
  • ◆"Great Doctors, Latest Medical treatments for 2009 " / Weekly Asahi Special Issue (weekly magazine) October 28, 2008 issue
  • ◆"Vol.52 Best doctors for breast reconstruction, latest treatments " / Weekly Asahi (weekly magazine) October 14,2008 issue
  • ◆"Breast Reconstruction Color Atlas" Nagai Co. Books [first edition published October 1, 2008] Hiroko Yanaga and Kunihiko Nohira
  • ◆"Miracles by the best Doctors” (Book) first edition first printing issued May 30 2008
  • ◆Featured article on "Seven Women" magazine July 2006 issue
  • ◆(TV) 21:00 ~ 23:00 / Fuji TV series broadcast nationwide [19 May 2006] "Friday entertainment, special program: medical miracles using state of the art technologies, Special family life bonds created by great doctors", "FILE No.3, breast reconstruction, Dr. Hiroko Yanaga"


  • <Main Bibliography>
  • 1.Cryopreserved cultured epidermal allografts achieved early closure of wounds and reduced scar formation in deep partial-thickness burn wounds (DDB) and split –thickness skin donor sites of pediatric patients. H.Yanaga, Burns 27, 689-698,2001
  • 2.Take percentage and conditions of cultured epithelium were improved when basement membrane of the graft was maintained and anchoring mesh was added. Yanaga H, Plast Reconstr Surg. 107:105-115, 2001
  • 3.Long-term viability of cryopreserved cultured epithelial grafts. Udoh Y,& Yanaga H, Burns 27, 535-542,2000
  • 4.Nipple-areola reconstruction with a dermal-fat flap: technical improvement from rolled auricular cartilage to artificial bone. H. Yanaga, Plast Reconstr Surg. 112:1863-1869, 2003
  • 5.Clinical application of biotechnically cultured autologous chondrocytes as novel graft material for nasal augmentation. H. Yanaga et al. Aesth Plast Surg. 28:212-221, 2004
  • 6.Clinical application of cultured autologous human auricular chondrocytes with autologous serum for craniofacial or nasal augmentation and repair. H. Yanaga, Plast Reconstr Surg. 117:2019-2030, 2006
  • 7.Generating ears from cultured autologous auricular chondrocytes by using two-stage implantation in treatment of microtia. H. Yanaga. Plast Reconstr Surg. 124:817-825, 2009
  • 8.Generative surgery of cultured autologous auricular chondrocytes for nasal augmentation. H. Yanaga, Aesth Plast Surg 33:795-802 2009
  • 9.Cell-Engineered human elastic chondrocytes regenerate natural scaffold in Vitro and neocartilage with neoperichondrium in human body post-transplantation. H.Yanaga, Tissue Engineering Part A 18:2020-2029,2012
  • 10.Two-stage transplantation of cell-engineered autologous auricular chondrocytes to regenerate chondrofat composite tissue: clinical application in regenerative surgery. H. Yanaga. Plast Reconstr Surg. 132:1467-1477, 2013
  • 11.Plastic Surgery,3d edition, 2012 Elsevier Saunders Tissue engineering p419~423
  • 12.15. Correction of secondary deformity after Nuss procedure for pectus excavatum by means of cultured autologous cartilage cell injection.Tamai M & Yanaga H Int. J Surg Case Rep. 15:70-73,2015
  • <Awards>Best free paper, 19th Congress of ISAPS, Melbourne Australia February 10-13,2008
  • <Grants>Research work was supported by Grand No.10877287 of the Grant–in-Aid for Scientific Research from the Ministry of Education.

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2018.10.31-11.4
ISAPS 2018 The 24th Congress (Miami, USA) (Speaker)
Title: Cell-engineered cartilage grafts in secondary rhinoplasty
Hiroko Yanaga

(2018.8.9-10,Panel(Speaker)
 8th International Congress of PAAFPRS (Yokohama, JAPAN))

2017.9.4-7
5th TERMIS World Congress-2018 Kyoto, Japan (Kyoto, JAPAN) (Speaker)
Title: Clinical application using autologous cell-engineered chondrocytes transplantation in aesthetic and reconstructive surgery
Hiroko Yanaga, Keisuke Imai, Masayuki Miyata, Ken Matsuda, Katsu Yanaga

2016.12.1-3
The 11th Congress of the Asian Pacific Craniofacial Association(APCA2016) (Nara, Japan)
Title: Regenerated ears from auricular chondrocytes by using two-stage implantation in microtia treatment
Hiroko Yanaga, Keisuke Imai, Katsu Yanaga

2016.10.23-27
International Society of Aesthetic Plastic Surgery (ISAPS) 2016 23rd Congress (Kyoto, Japan)
(Speaker)
Title: Enhancing of Mid Facial Rejuvenation with Microlipo-Injection.
Hiroko Yanaga
Title: Breast Augmentation with Cell-Enginneered Adipocyte and Fat Injection.
Hiroko Yanaga

2016.9.23-27
American Society of Plastic Surgery The Meeting 2016 (Los Angeles, USA)
(Speaker Panel)
Title: Guest Nation Panel : Innovative Plastic Surgery from Japan「Reconstruction and Augmentation of Deformity.」
Hiroko Yanaga

2014.9.19-22
International Society of Aesthetic Plastic Surgery 22nd Congress (ISAPS) (Rio de Janeiro, Brazil)
(Speaker Panel)
Title: Combination therapy of ultra-pulse CO2 laser abrasion and cell-engineered keratinocytes grafts for severe acne scars.
Hiroko Yanaga
Title: New technique of cell-engineered auricular chondrocytes for secondary rhinoplasty.
Hiroko Yanaga

2014.3.2-4
International Society of Amesthetic Plastic Surgery Instructional Course (ISAPS) (Philippin)
(Speaker)
Title: New clinical application of cultured epithelial grafts in regenetative surgery.
Hiroko Yanaga
(Speaker)
Title: Cultured auricular chondrocytes (CAC) and their clinical application in regenerative surgery.
Hiroko Yanaga

2013.4.11-16
The aesthetic meeting 2013 (Tokyo, Japan)
(Speaker ,Free paper)
Title: Nasal augmentation using two stage implantation of cultured autologous auricular chondrocytes.
Hiroko Yanaga, Keisuke Imai, Katsu Yanaga

2012.9.4-8
21th Congress, International Society of Aesthetic Plastic Surgery (Geneva, Switzzerland)
(Speaker ,Free Paper)
Title: Cell-engineered cultured auricular chondrocytes: basic science, surgical technique and clinical application in generative cartilage surgery.
Hiroko Yanaga

2012.5.22 
Regenerative Medical of Skin and Related Organs (Harvard University, USA)
(Speaker,Symposium)
Title: New clinical application of cultured epithelial grafts in regenetative surgery.
New clinical application of cultured chondrocytes in regenetative surgery.
Hiroko Yanaga

2011.10.7-9
The 3rd Asian Symposium of Breast Plastic and Reconstructive Surgery (seoul)
(Speaker)
Title: Management of contra lateral breast.
Hiroko Yanaga

2011.8.17-22
The third ISAPS china course
(Speaker,Symposium)
Title: Total aesthetic breast reconstruction.
Hiroko Yanaga

2010.11.25-27
The 3rd International Oncoplastic Breast Surgery Symposium+ASBPRS2010 (Tokyo, Japan)
(Speaker)
Title: Total aesthetic breast reconstruction.
Hiroko Yanaga

2010.11.1-3
The 12th International Congress of Oriental Society of Aesthetic Plastic Surgery (Tokyo, Janan)
(Speaker,Panel Discussion)
Title: Generative surgery of cultured autologous auricular chondrocytes for nasal augmentation.
Hiroko Yanaga, Keisuke Imai, Katsu Yanaga

2010.8.14-18
20th Congress / International Society of Aesthetic Plastic Surgery (San Francisco, USA)
(Speaker,Free Paper)
Title: Generative surgery of cultured autologous auricular chondrocytes for nasal and chin augmentation by using two-stages implantation.
Hiroko Yanaga, Katsu Yanaga

2010.6.16-18
The 10th Korea-Japan Congress of Plastic & Reconstructive Surgery (Speaker,Special Lecture)
Title: Generative surgery by using culture autologous auricular chondrocytes for nasal, chin and craniofacial augmentation and microtia treatment: from cells to tissue.
Hiroko Yanaga
(Speaker,Panel)
Title: Inframammary lateral approach to augmentation mammaplasty. Hiroko Yanaga
(Speaker,Panel)
Title: Generative surgery of cultured autologous auricular chondrocytes for nasal augmentation.
Hiroko Yanaga

2009.10.9
IPRAS/APS 2009 (Japan, Tokyo)
(Speaker, free paper)
Title: Generating ears from cultured autologous auricular chondrocytes by using two-stage implantation in microtia treatment.
Hiroko Yanaga
(Speaker Panel Discussion)
Title: Generative surgery of cultured autologous auricular chondrocytes for nasal augmentation.
Hiroko Yanaga

2008.2.10-13
19th Congress International Society of Aesthetic Plastic Surgery (Melbourne, Australia)
(Speaker Free Paper)
Title: Clinical application of cultured autologous human auricular chondrocytes for nasal augmentation.
Hiroko Yanaga

2007.10.26-31
American society of plastic surgeons / Plastic Surgery 2007(Baltimore, USA)
(Speaker Free Paper)
Title: Clinical application of cultured autologous human auticular chondrocytes to cranio-facial, nasal and/or ear reconstruction: overall results in basic studies and 60 patients.
Hiroko Yanaga, Keisuke Imai, Katsu Yanaga

2006.2.1-4
40th Baker Gordon Symposium on Cosmetic Surgery (Miami, USA)
Hiroko Yanaga

2004.8.22-26
The 12th Congress of the International Society for Burn Injuries (Kanagawa, Japan)
Title:Poster
Hiroko Yanaga

2003.10.24
La Chirurgia Ricostruttiva Ed Estetica Del Distretto Cefalico (Padova, Italy)
Title: Tissue Engineered Human Auricular Chondrocytes and Its Clinical Application for craniofacial and nasal augmentation
Hiroko Yanaga
(Speaker)

2002.10.21-23
The 4th Asian Pacific Craniofacial Association CONFERENCE-Tokyo 2002 (Tokyo, Japan)
(Speaker Free Paper)
Title: Clinical application of tissue engineered human auricular chondrocytes.
Hiroko Yanaga

2002.6.21-22
Attualit'a e Controversie in Oncologia Oculare e Orbitaria (Padova, Italy)
Title: La ricostruzione dopo exenteratio orbitae.
Hiroko Yanaga
(Speaker)

2000.4.24-26
The 5th Korea-Japan Congress of Plastic and Reconstructive Surgery (Tokyo, Japan)
(Speaker Free Paper)
Title: An ipsilateral superdrainaged tram flap for breast reconstruction.
Hiroko Yanaga, Y. Tai, Y. Inoue, K. Kiyokawa

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I believe that as we grow older, looking beautiful will help us enjoy more fulfilling lifestyles, it is in human nature to try to look beautiful even as we age. After working in the fields of cosmetic and reconstructive surgery and regenerative medicine for over 28 years I am convinced that being healthy is the most important factor that leads us to look beautiful. We look our best when we are the healthiest. If we provide our body with the right nutrients to stay healthy beauty will follow. Our food defines our body and it can also be its best medicine. Eating well, exercising, laughing will lead us to health. Proper care and supplying the skin with the nutrients it needs to stay healthy will lead us to have beautiful skin.